Pharma-grade skincare
that fights flare-ups
Powered by patent-pending XDFTM technology to reduce and protect from irritation and break-outs
Clinically proven essentials.
- Skincare
- Discovery Size
- LIP HEALTH
DERMATOLOGIST RECOMMENDED
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EWG-VERIFIED
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CLINICALLY TESTED
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AVAILABLE AT FORMULA FIG
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Clinically proven results powered by our patent-pending XDFTM delivery system.
AI,24
- Reduced inflammation & redness
- Improved active acne
- Balanced skin health
Naila, 27
- Balanced skin microbiome
- Improved tone & texture
- Reduced breakouts and redness
Mia, 34
- Reduced redness and visible inflammation
- Faster visible recovery through the flare cycle
- Improved comfort without dryness or cracking
Pharmaceutical discipline, not cosmetic convention
Pharmaceutical R&D platform
End-to-end product development led by scientists with drug-delivery expertise, from molecule selection to finished formulation.
Independent, third-party testing
Key claims supported by external labs and clinical partners to ensure objectivity and reproducibility.
Biological validation, not perception
Performance measured through permeability studies, cellular assays, and clinical evaluation, not consumer surveys alone.
Mechanism-first formulation
We explain not just what works, but why it works, down to delivery, absorption, and biological response.
We believe credibility should be quantifiable. Here’s what backs MARK so far.
400×
Better Vs. Traditional Skincare: Independent flux measurements vs. published literature baseline
95-100%
Inflammatory marker reversal - IL-6, IL-8, TNF-α, CRP suppression in stressed fibroblast assays
75%
Transdermal delivery: Franz Cell studies confirm 75% of applied flavonoids reach viable skin tissue
20+
Years Pharmaceutical R&D - Gilead Sciences (HIV therapeutics) + Nucleo Life Sciences (clinical-stage programs)
XDF™
Pharmaceutical delivery, optimized for skin.
XDF™ (Transdermal Flavosomes) is a patent-pending delivery system derived from pharmaceutical drug-delivery science. It dissolves, stabilizes, and transports bioactive molecules through the skin barrier so they can perform where inflammation, repair, and regeneration actually occur.
Engineered by drug developers, not beauty marketers.
After two decades in pharmaceutical drug delivery, our founder applied the same scientific rigor to skincare.
The goal wasn’t trendy ingredients or better packaging. It was to build formulas that actually reach their target and work safely, consistently, and measurably.
Respectful by design.
Every MARK formula is engineered to be effective enough to solve visible conditions, and gentle enough for daily use.
No harsh actives
No unnecessary fragrance
No aesthetic filler
What people are saying
Let customers speak for us
from 126 reviewsI'm a huge fan of the Rescue Serum, so love to see it in a travel size!
This light moisturizer feels like it was custom made for my ultra sensitive skin. It is lightweight yet provides ample moisturizer so my skin doesn't feel tight. It doesn't cause any redness or stinging. The 3 main ingredients are perfect for our hot and humid climate in the deep south They are squalane, jojoba oil and coconut triglycerides. All of which are soothing and hydrating. Highly recommend!
I’m in love with the Mark Los Angeles moisturizer! A little goes a long way, so it’s definitely worth the investment. Just a small amount provides deep hydration that keeps my skin feeling soft and plump throughout the day. It’s lightweight, non-greasy, and absorbs beautifully, leaving my face feeling nourished without any heaviness. I’ve noticed that my skin feels firmer and looks healthier since I started using it. In fact, it has extended the interval between my injection treatments! What I love most is that it’s made with clean ingredients—this is important to me, and it gives me peace of mind knowing I’m putting something pure on my skin. This moisturizer has become an essential part of my daily routine and will continue to be!
Was looking for a good daily moisturizer to add to my routine. This one from Mark Los Angeles uses premium ingredients, plant-based, and packed with plant flavonoids, quersetin, jojoba oil, and coconut triglycerides. It feels really good on my skin. It doesn’t weigh it down or clog my pores. Builds a nice moisture barrier. I do feel it reduced inflammation and redness on my sensitive skin. Made in USA. 🇺🇸
This is an exfoliating cleanser by MARK Los Angeles.
The box says "ECGC + Quercetin" as key ingredients, but it also has squalane oil and castor oil. It uses walnut shells for exfoliation.
It goes on like any other comparable cleanser and it does a decent job of making the face feel clean and refreshed. The plant based ingredients are a plus for me, and I like the minimal list of ingredients to get a viable product.
I had no redness or irritation after using this and I'd say my skin is normal and perhaps a bit sensitive.
Overall, this is an effective cleanser and I have made it a part of my beauty ritual.
This is a nice smooth gel cleanser with gentle exfoliation beads. It cleans well and causes no sensitivity issues. My hubby and I are both using it, and it works well for my dry sensitive skin and his tough oily skin. Highly recommend for all skin types.
This exfoliating cleanser is pretty good. It has very fine particles in it that exfoliate gently and gradually so it doesn't cause irritation or redness. It doesn't suds up much but it definitely made my skin cleaner and smoother. I also like the glass bottle this came in. It has a sturdy pump top with a pump protector so it was well sealed - there was no leakage enroute unlike with other liquids I have gotten on Amazon. This was expensive for a facial cleanser but if it comes with a good coupon it is worth getting.
The E.Q. Exfoliating Cleanser works really well on my aging skin. Every now and then, I might get a breakout, so I need something that helps keep them under control or, better yet, prevents them altogether. It’s super easy to get the cleanser out of the bottle, and I like that just a small amount lathers up nicely, leaving my skin feeling really clean. After using it with my favorite toner, I’ve noticed fewer dark spots on my face, which is a big plus. The scent is so relaxing—it makes my skincare routine feel like a little treat. I love that it’s made with plant-based ingredients because it doesn’t dry out my skin at all. And the dark bottle? A smart touch since it helps protect the product from light. This has definitely become my go-to when I need that extra-deep clean feeling.
Some days, I need something very simple and gentle to cleanse all the sunscreen and makeup off my sun- and wind-irritated face. I work outdoors, which can be very rough on skin, but am diligent about caring for it.
I've tried many cleansers. On heavy SPF days, many can't get all the residue off. Some have too much graininess and feel like they're taking some of my actual skin off with the residue. This cleanser is right in the middle. I can feel the exfoliating granules (which are made from walnut shells--no microplastics here!) but there are not too many of them, and they are softer-textured and smaller than those heavy exfoliants from the 90s.
I appreciate the short, simple ingredient list; I'm picky about what I put in and on my body. This would work well for more sensitive skins. No heavy fragrance. After washing, my skin felt clean and free of sunscreen residue, but not stripped, dry, or tight.
This EQ Exfoliating Cleanser by Mark Los Angeles is a high quality cleanser that is plant based with squalane, EGCG, quercetin and other antioxidants. I love that it is basically unscented and that it is made in the USA! The exfoliant that is used in this product are walnut shells instead of plastic beads which is so much better for the environment. The exfoliant is mild but feels very effective. My face feels very clean and not too dried out after using. I like that the consistency of this is more of a cleanser versus an exfoliant as I feel I could use this twice a day with no issues. Sometimes exfoliants are too thick and gritty and you only can use it every few days because of that. Not with this product! The glass bottle makes this cleanser feel very high end and the pump is easy to use and close for travel with the included safety cap. My husband and teen daughter has also tried this cleanser out and loved how clean it made their skin. Now I just need to hide it from them so they don’t keep using it. Highly recommended!
I had a blemish and applied the product on early in the morning. When I got back home from work I did not see any redness and it appeared to be on the mend much quicker than other products that I've used. It is different as the viscosity is thicker than most oils. Overall, I'm please with this product.
Now let me just say me and my daughter love this product and we where both skeptical about it
Bit no it's true it truly tarted clearing my daughter's face up after one use no joke and her face is looking great after 3 uses but not completely clear yet and why I love it well I found that it makes my wrinkles disappear every use and it's like it softens the skin and my wrinkles just fall right off so I put it on rub it in then let it dry the pull and there gone well I pull a few times if it's not completely gone but it really works and it is sticky at first but give it a few seconds to dry and smooth skin no sticky residue but seriously this is a wonderful product but it does have a big price tag but you only need a tiny amount to so it will last a minute
And it does dry mat so no glossy look or greasy.
So yes it truly does what it says and I can't be happier with it.
The E.Q. Rescue Serum has been a wonderful addition to my skincare routine. It has a lightweight, non-greasy formula that absorbs quickly, leaving my skin feeling refreshed and hydrated. With consistent use, I’ve noticed a reduction in redness and fewer blemishes. It's gentle and works well under makeup, making it easy to incorporate daily. A great option for those looking to calm and clarify their skin!
E.Q. Rescue Serum feels great going on, and I feel like it makes my skin feel more firm and lifted. It’s also more smooth, moisturized and healthy looking. Initially this product appealed to me for its unique anti-inflammatory properties and it’s truly remarkable how quickly I noticed dramatic improvements in radiance & texture. Plus, the packaging is beautiful & the bottle design makes it super easy to use the right amount of product. I love using this product both day and night - it works well both under other products & makeup. I use it with products from MARK and other brands and am overall so happy with the efficacy.
Individual results may vary
Frequently Asked Questions
What is XDF™?
XDF™ is MARK’s proprietary delivery system developed from pharmaceutical drug-delivery science. Based on pharmaceutical drug-delivery science, it transports flavonoids into dermis without barrier disruption.
How is MARK different from traditional skincare?
Traditional skincare focuses on surface effects. MARK is engineered for absorption and validated through permeability studies, cellular assays, and clinical evaluation.
What skin concerns does MARK address?
Breakouts, redness, irritation, barrier disruption, and recurring flare-ups driven by inflammation.
Is MARK safe for sensitive skin?
Yes. All formulas are designed to be effective without being aggressive and are free from fragrance, essential oils, and unnecessary additives.
How long does it take to see results?
Some users notice calmer skin within days. Sustained improvements typically develop with consistent use over several weeks.
Why doesn’t MARK market active percentages?
Because delivery matters more than concentration. Most brands list 10-20% vitamin C to compensate for 0-5% absorption. We engineer delivery systems that work at lower, safer concentrations—75% of applied dose reaches target tissue allowing us to optimize for a lower dose.
What does "75% transdermal delivery" mean?
In Franz Cell studies (FDA gold standard for topical delivery), 75% of applied flavonoids crossed excised human skin into the receptor chamber at 24 hours. This confirms actives reach viable dermis, not just surface. Conventional formulations typically achieve 1-5%.
How is 400× better delivery possible?
Published literature shows conventional flavonoid formulations deliver 0.1-2 µg/cm²/hr. XDF™ achieves 418 µg/cm²/hr in Franz Cell studies. That's 200-4,000× higher flux. Even conservative estimates accounting for methodology differences indicate 50-200× improvement—fundamentally different transport kinetics.
Is this actually pharmaceutical-grade?
Our development process uses pharmaceutical methodologies: FDA-standard Franz Cell testing, BioMAP validation platforms, stressed fibroblast assays, and clinical trials. Our founder developed FDA-approved drugs at Gilead Sciences. The products are cosmetics, but the science is drug development rigor.